Advances in molecular mechanism of cardioprotection induced by helium
نویسندگان
چکیده
Helium has been classified as a kind of inert gas that is not effortless to spark chemical reactions with other substances in the past decades. Nevertheless, the cognition of scientists has gradually changed accompanied with a variety of studies revealing the potential molecular mechanism underlying organ-protection induced by helium. Especially, as a non-anesthetic gas which is deficient of relevant cardiopulmonary side effects, helium conditioning is recognized as an emerging and promising approach to exert favorable effects by mimicking the cardioprotection of anesthetic gases or xenon. In this review we will summarize advances in the underlying biological mechanisms and clinical applicability with regards to the cardioprotective effects of helium.
منابع مشابه
Investigating the role of acute and repeated stress on remote ischemic preconditioning-induced cardioprotection
Objective(s): To study the effect of acute and repeated stress on cardioprotection-induced by remote ischemic preconditioning (RIPC).Materials and Methods: RIPC was induced by giving 4 short cycles of ischemia and reperfusion, each consisting of five min. The Langendorff’s apparatus was used to perfuse the isolated rat hearts by subjecti...
متن کاملExploring the role and inter-relationship among nitric oxide, opioids, and KATP channels in the signaling pathway underlying remote ischemic preconditioning induced cardioprotection in rats
Objective(s): This study explored the inter-relationship among nitric oxide, opioids, and KATP channels in the signaling pathway underlying remote ischemic preconditioning (RIPC) conferred cardioprotection. Materials and Methods: Blood pressure cuff was placed around the hind limb of the animal and RIPC was performed by 4 cycles of infla...
متن کاملThe Role of Exercise Preconditioning in Cardioprotection against Ischemia Reperfusion Injury
Cardiovascular diseases are still the main cause of mortality around the world. Therefore, it is essential to develop practical means to reduce their burden. A wealth of evidence supports the role of physical exercise in attenuating many of the risk factors of cardiovascular diseases. Moreover, endurance training warrants protection against myocardial infarction. Exercise, even if performed ...
متن کاملEffects of Low-Level Helium-Neon Laser Therapy on Healing of Partial Thickness Defect of Experimental Induced Diabetic Rats
Purpose: The aim of present study was to study the effects of low-level helium–neon laser irradiation on biomechanical properties of tibiae partial bone defect in streptozotocin–diabetic rat. Materials and Methods: Twenty male rats were used .Diabetes was induced in rats by one time intraperitoneal injection of 60 mg/kg streptozotocin .After one month ,under sterile conditions and general anes...
متن کاملOleuropein cardioprotection effect against oxidative stress in Streptozotocin-induced diabetic male rats
Introdution: Diabetes is the most common endocrine disorder characterized by hyperglycemia. Increasing the oxidative stress and changing the amount of antioxidants play important roles in pathogenesis of diabetes. Nowadays to control diabetes and its complications, the use of herbal drugs is considered widely. In this study, we investigated the effect of oleuropein on antioxidant enzymes activi...
متن کامل